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SML1035

ICA-121431

≥98% (HPLC)

Synonym(s):

α-Phenyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-benzeneacetamide

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$131.00
$111.35
25 mg

Available to ship TODAYfromMILWAUKEE

$525.00
$446.25

About This Item

Empirical Formula (Hill Notation):
C23H19N3O3S2
CAS Number:
313254-51-2
Molecular Weight:
449.55
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

$111.35

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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

room temp

SMILES string

[S](=O)(=O)(Nc4[s]ccn4)c1ccc(cc1)NC(=O)C(c3ccccc3)c2ccccc2

InChI

1S/C23H19N3O3S2/c27-22(21(17-7-3-1-4-8-17)18-9-5-2-6-10-18)25-19-11-13-20(14-12-19)31(28,29)26-23-24-15-16-30-23/h1-16,21H,(H,24,26)(H,25,27)

InChI key

URSQNPPONHUJDL-UHFFFAOYSA-N

Biochem/physiol Actions

ICA-121431 is a potent, selective inhibitor of the human Nav1.3 and Nav1.1 voltage gated sodium channels (IC50 = 19 nM) with little or no activity against human Nav1.5 or Nav1.7 channels.
ICA-121431 is a potent, selective inhibitor of the human Nav1.3 and Nav1.1 voltage gated sodium channels.
ICA-121431 [2,2-diphenyl-N-(4-(N-thiazol-2-ylsulfamoyl)phenyl) acetamide, a small molecule inhibitor, targets the extracellular amino acids in S2 and S3 in VSDIV (domain IV voltage sensor), which is essential for Hm1a efficacy. In humans, ICA-121431 blocks TTX-sensitive Nav1.3 sodium channels upregulated in HEK-293 cells.[1]

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This Item
SML1626SML0355SML1189
ICA-121431 ≥98% (HPLC)

Sigma-Aldrich

SML1035

ICA-121431

TFCA ≥98% (HPLC)

Sigma-Aldrich

SML1626

TFCA

BCTC ≥98% (HPLC)

Sigma-Aldrich

SML0355

BCTC

4-P-PDOT ≥98% (HPLC)

Sigma-Aldrich

SML1189

4-P-PDOT

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: 25 mg/mL, clear

solubility

DMSO: >10 mg/mL

solubility

DMSO: 5 mg/mL, clear (warmed)

color

white to beige

color

white to beige

color

white to beige

color

white to beige

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 4 - Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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