SML0574

YM-298198 hydrochloride

≥98% (HPLC)

• Synonym(s): 6-Amino-N-cyclohexyl-N,3-dimethyl-thiazolo[3,2-a]benzimidazole-2-carboxamide hydrochloride
• Empirical Formula (Hill Notation): C₁₈H₂₂N₄OS · HCl
• CAS Number: 1216398-09-2
• Molecular Weight: 378.92
• NACRES: NA.77
• PubChem Substance ID: 329825561
• UNSPSC Code: 12352200
• MDL number: MFCD08703122
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: 5 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: Cl.CN(C1CCCCC1)C(=O)c2sc3nc4ccc(N)cc4n3c2C
• InChI: 1S/C18H22N4OS.ClH/c1-11-16(17(23)21(2)13-6-4-3-5-7-13)24-18-20-14-9-8-12(19)10-15(14)22(11)18;/h8-10,13H,3-7,19H2,1-2H3;1H
• InChI key: WYTJVUVCSUWZTH-UHFFFAOYSA-N

Description

Biochem/physiol Actions

YM-298198 is a selective, noncompetitive mGlu1 receptor antagonist.

YM-298198 is an orally active, noncompetitive mGlu1 receptor antagonist. The compound inhibits glutamate-induced inositol phosphate production in NIH3T3 cells (IC₅₀ = 16 nM). YM-298198 displays analgesic and antinociceptive properties in vivo.

Features and Benefits

This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable