ABL127 jest silnym i selektywnym inhibitorem fosfatazy białkowej metyloesterazy-1 (PME-1 lub PPME-1).
ABL127 jest silnym i selektywnym inhibitorem fosfatazy białkowej metyloesterazy-1 (PME-1 lub PPME-1). Wartości IC50 wynosiły 11,1 nM i 6,4 nM w komórkach MDA-MB-231 i HEK 293T, przy czym nie wykryto aktywności wobec >50 innych hydrolaz serynowych. PME-1 reguluje stan metyloestryfikacji fosfatazy białkowej 2A (PP2A) i jest zaangażowany w raka i neurodegenerację.
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Journal of biochemistry, 168(6), 643-650 (2020-07-15)
Bone marrow-derived mesenchymal stem cells (BM-MSCs) are multipotent stem cells with ability to self-replicate and differentiate into mesodermal derivatives, such as adipocytes and osteoblasts. BM-MSCs are a critical component of the tumour microenvironment. They support tumour progression by recruiting additional
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 17(4), 1878-1896 (2020-09-23)
The molecular mechanism of Alzheimer-like cognitive impairment induced by manganese (Mn) exposure has not yet been fully clarified, and there are currently no effective interventions to treat neurodegenerative lesions related to manganism. Protein phosphatase 2 A (PP2A) is a major
Reversible methyl-esterification (methylation) of Leu309 in the protein phosphatase 2A catalytic subunit (PP2Ac) is essential for proper biogenesis of the PP2A holoenzyme. Accumulating evidence links PP2Ac methylation to diseases, including cancer and neurodegenerative disorders. Protein phosphatase methyl-esterase (PME-1) specifically catalyzes
Protein phosphatase methylesterase 1 has been identified as a novel gene in skeletal muscle that is upregulated in response to neurogenic atrophy in mice. Western blot analysis confirms that Ppme1 is expressed during both muscle cell proliferation and differentiation. Additionally
Frontiers in immunology, 12, 648913-648913 (2021-04-30)
The excessive M1 polarization of macrophages drives the occurrence and development of inflammatory diseases. The reprogramming of macrophages from M1 to M2 can be achieved by targeting metabolic events. Taurine promotes for the balance of energy metabolism and the repair
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