SML0016

CCG-63802

• Synonym(s): α-[[9-Methyl-2-(3-methylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]methylene]-2-benzothiazoleacetonitrile
• Empirical Formula (Hill Notation): C₂₆H₁₈N₄O₂S
• CAS Number: 620112-78-9
• Molecular Weight: 450.51
• NACRES: NA.77
• UNSPSC Code: 12352200
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• assay: ≥98% (HPLC)
• Quality Segment: 100
• form: powder
• color: yellow
• solubility: DMSO: ≥5 mg/mL (;warmed DMSO)
• storage temp.: room temp

Description

Application

CCG-63802 may be used to study G-protein-mediated cell signaling.

Biochem/physiol Actions

CCG-63802 is a reversible, allosteric inhibitor of RGS4

GCC-63802 binds to RGS4 and blocks interaction with Goa (IC50 = 1.9 uM). RGS4 (Regulator of G protein Signaling) is one of the RGP proteins responsible for terminating mu opioid receptor signaling. RSG proteins are GTPase activators, and drive G protein subunits to an inactive, GDP-bound form.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the G Proteins (Heterotrimeric) and Opioid Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable