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S6942
Staurosporine solution from Streptomyces sp.
Ready Made Solution, 1 mM in DMSO (100 μg/214 μL)
Synonym(s):
Antibiotic AM-2282
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| Size/SKU | Availability | Price |
|---|---|---|
200 μL | Check Cart for Availability | $356.00 |
About This Item
Assay:
>98% (HPLC)
$356.00
Check Cart for Availability
Product Name
Staurosporine solution from Streptomyces sp., Ready Made Solution, 1 mM in DMSO (100 μg/214 μL)
Quality Segment
assay
>98% (HPLC)
concentration
1 mM in DMSO (100 μg/214 μL)
technique(s)
cell culture | mammalian: suitable
antibiotic activity spectrum
fungi
mode of action
enzyme | inhibits
shipped in
wet ice
storage temp.
−20°C
General description
Chemical structure: indol derivative
Application
Staurosporine solution from Streptomyces sp. was used to study the effect of PKC inhibition on signaling mediated by angiotensin II.3 It was used to induce cell death in Jurkat cells.4
Biochem/physiol Actions
Potent cell-permeable inhibitor of protein kinase C. Induces apoptosis in Jurkat cells.
Potent inhibitor of phospholipid/calcium-dependent protein kinase. Inhibits the upregulation of VEGF expression in tumor cells.
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This Item | |||
|---|---|---|---|
| assay >98% (HPLC) | assay ≥98% (HPLC) | assay ≥95% (HPLC) | assay ≥97% (HPLC) |
| Quality Level 300 | Quality Level 300 | Quality Level 300 | Quality Level 100 |
| technique(s) cell culture | mammalian: suitable | technique(s) - | technique(s) - | technique(s) - |
| storage temp. −20°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −70°C |
| shipped in wet ice | shipped in - | shipped in - | shipped in wet ice |
| concentration 1 mM in DMSO (100 μg/214 μL) | concentration - | concentration - | concentration - |
Storage Class
10 - Combustible liquids
flash_point_f
188.6 °F - closed cup
flash_point_c
87 °C - closed cup
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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What concentration of Staurosporin is used for the release of microparticles from apoptotic cells?
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Staurosporin can induce apopotosis in Jurkat cells (106/ml) at 1 ug/ml following a 1-2 hour incubation at 37°C. For the release of microparticles from apoptotic Jurkat cells, use staurosporin at 1 uM for 107 cells/ml. Please see the reference below for further details. Apoptosis 15(5):586, 2010.
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