S0819

Anti-Sodium Channel Na_V1.5 antibody produced in rabbit

affinity isolated antibody, lyophilized powder

• Synonym(s): Anti-SKM2, Anti-Scn5a
• UNSPSC Code: 12352203
• NACRES: NA.41
• MDL number: MFCD04975341
• Conjugate: unconjugated
• Clone: polyclonal
• Application: WB
• Citations: 19

Properties

• biological source: rabbit
• Quality Segment: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: lyophilized powder
• species reactivity: rat
• technique(s): western blot: 1:200 using rat heart membranes
• UniProt accession no.: P15389
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... SCN5A(6331) ; mouse ... Scn5a(20271) ; rat ... Scn5a(25665)

Description

General description

SCN5A (sodium voltage-gated channel α subunit 5) codes for an α subunit of the cardiac sodium channel (NaV1.5). It is located on human chromosome 3p22.2.

Immunogen

peptide corresponding to amino acid residues 493-511 of rH1 (Accession P15389). This epitope is identical in mouse and highly homologous in human (17/19 residues identical).

Application

Anti-Sodium Channel NaV1.5 antibody produced in rabbit has been in immunoblotting and immunofluorescence.[1]

Biochem/physiol Actions

SCN5A (sodium voltage-gated channel α subunit 5) regulates the movement of sodium ions into cells, which helps in the production and diffusion of electrical impulses. SCN5A mutations results in the loss or gain of sodium channel activity and cause several cardiac diseases like Brugada syndrome, Long QT syndrome type 3, Sick sinus syndrome and progressive familial heart block.

Physical form

Lyophilized at ~0.8 mg/mL in phosphate buffered, pH 7.4, containing 1% bovine serum albumin, and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable