P9255

Pyridoxal 5′-phosphate hydrate

≥98%

• Synonim(y): Pyridoxal phosphate, 3-Hydroxy-2-methyl-5-([phosphonooxy]methyl)-4-pyridinecarboxaldehyde, Codecarboxylase, PLP, Pyridoxal 5-phosphate
• Wzór empiryczny (zapis Hilla): C₈H₁₀NO₆P · xH₂O
• Numer CAS: 853645-22-4
• Masa cząsteczkowa: 247.14 (anhydrous basis)
• Beilstein: 234749
• Numer WE: 200-208-3
• Numer MDL: MFCD00006333
• Kod UNSPSC: 12352205
• Identyfikator substancji w PubChem: 24899020
• NACRES: NA.79

Właściwości

• pochodzenie biologiczne: synthetic (organic)
• Próba: ≥98%
• Postać: powder
• metody: HPLC: suitable
• kolor: beige; off-white to yellow
• mp: 140-143 °C
• temp. przechowywania: −20°C
• ciąg SMILES: CC1=NC=C(COP(O)(O)=O)C(C([H])=O)=C1O
• InChI: 1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
• Klucz InChI: NGVDGCNFYWLIFO-UHFFFAOYSA-N

Opis

Opis ogólny

Pyridoxal 5′-phosphate (PLP) is synthesized in a multiple-step process. The two pathways inlcude pyridoxal phosphate biosynthetic protein (PdxA)- pyridoxine-5′-phosphate synthase (PdxJ) pathway and the pyridoxal 5′-phosphate synthase subunit PDX1/PDX2 pathway. It is the active form of pyridoxine.

Zastosowanie

Pyridoxal 5′-phosphate hydrate has also been used:

• as a reference standard to quantify vitamin B₆ in feed and digesta samples using high performance liquid chromatography (HPLC)
• in D-amino acid transaminase reaction(10)
• as a cofactor for L-glutamic acid decarboxylase

Działania biochem./fizjol.

Pyridoxal 5′-phosphate (PLP) aids in carbohydrate and fat metabolism by serving as a cofactor. It is majorly responsible for catalyzing the enzymatic reactions involved in sphingolipid synthesis and neurotransmitter (dopamine and serotonin) synthesis. PLP is used in the studies of PLP-dependent enzyme active sites. PLP is also a cofactor for a wide range of enzymes including mitochondrial 5-Aminolevulinic acid synthase (ALAS) cysteine desulfurase, cystathionine γ-synthase (CGS), ornithine 4,5-aminomutase (OAM), and D-serine dehydratase.

Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)