This product is not tested for activity on a lot to lot basis. However, historical data show a range of 0.01 - 0.03 units per milligram.
P4506
Phosphodiesterase I from Crotalus atrox (Western Diamondback Rattlesnake)
Type IV, crude dried venom
Synonym(s):
5′-Exonuclease, Oligonucleate 5′-nucleotidohydrolase
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| Size/SKU | Availability | Price |
|---|---|---|
100 mg | Check Cart for Availability | $100.00 |
500 mg | Check Cart for Availability | $352.00 |
About This Item
UNSPSC Code:
12352204
NACRES:
NA.54
EC Number:
232-870-4
MDL number:
General description
Research area: Cell signalingPhosphodiesteraseI (PDEI) exists in three isoforms PDE1A,PDE1B, and PDE1C(2) that are locatedin cardiovascular, central nervous system, and other organs.[1]
Application
Phosphodiesterase I from Crotalus atrox (Western Diamondback Rattlesnake) has been used to analyse its effect on intracellular calcium concentration of neutrophils. It has also been used in combination with other enzymes to determine the activity of phosphatase enzyme.
Phosphodiesterase I, product P4506 from western diamondback rattlesnake, is used in phosphodiesterase activation assays for calmodulin. It is added to hydrolyze AMP[2].
Biochem/physiol Actions
Phosphodiesterase I breaks phosphodiester bonds and catalyzes the hydrolysis of various nucleotide polyphosphates[2][3]. Phosphodiesterase I is released from eucaryotic plasma membranes by phosphatidylinositol-specific phospholipase C[4]. Phosphodiesterase I (PDEI) can hydrolyze 3′,5′-cyclicadenosine monophosphate (cAMP) and 3′,5′-cyclic guanosine monophosphate (cGMP).It forms a complex with Ca2+/calmodulin (CaM) that leads to the activationof its catalytic activity.PDEIshows biotherapeutic effects for the treatment of cancer, diseases, neurocognitive,pulmonary, metabolic, heart, renal, neurological disorders, and endocrineabnormalities.[1]
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This Item | |||
|---|---|---|---|
| form crude dried venom | form crude dried venom | form solid | form lyophilized powder |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| type Type IV | type Type VI | type - | type - |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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