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P4157

Phe-Arg β-naphthylamide dihydrochloride

cathepsin substrate, fluorogenic, ≥98% (TLC), powder

Synonym(s):

PAβN

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Size/SKUAvailabilityPrice
25 mg

Available to ship TODAYfromMILWAUKEE

$230.00
250 mg

Available to ship TODAYfromMILWAUKEE

$1,140.00

About This Item

Empirical Formula (Hill Notation):
C25H30N6O2 · 2HCl
CAS Number:
100929-99-5
Molecular Weight:
519.47
UNSPSC Code:
12352204
PubChem Substance ID:
24898508
NACRES:
NA.32
MDL number:
MFCD00058046

$230.00

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Product Name

Phe-Arg β-naphthylamide dihydrochloride, cathepsin substrate

Quality Segment

200

assay

≥98% (TLC)

form

powder

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

storage temp.

−20°C

SMILES string

Cl.NC(Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(=O)Nc2ccc3ccccc3c2

InChI

1S/C25H30N6O2.ClH/c26-21(15-17-7-2-1-3-8-17)23(32)31-22(11-6-14-29-25(27)28)24(33)30-20-13-12-18-9-4-5-10-19(18)16-20;/h1-5,7-10,12-13,16,21-22H,6,11,14-15,26H2,(H,30,33)(H,31,32)(H4,27,28,29);1H

InChI key

ZMTAZQYLEGNUTJ-UHFFFAOYSA-N

General description

Substrate for dipeptidyl aminopeptidase I (cathepsin C).
Phe-Arg β-naphthylamide, a peptidomimetic compound,[1] is an efflux pump inhibitor (EPI). It acts on the major multidrug resistance efflux transporters of Gram-negative bacteria. Phe-Arg -naphthylamide lowers fluoroquinolone resistance in Pseudomonas aeruginosa.[1]

Application

Phe-Arg -naphthylamide dihydrochloride has been used to evaluate the contribution of efflux pumps to antimicrobial resistance. It has also been used for minimal inhibitory concentration testing in the presence of an efflux pump inhibitor.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

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This Item
A3261H2508B7632
Phe-Arg β-naphthylamide dihydrochloride cathepsin substrate

Sigma-Aldrich

P4157

Phe-Arg β-naphthylamide dihydrochloride

Arg-Arg β-naphthylamide trihydrochloride

Sigma-Aldrich

A3261

Arg-Arg β-naphthylamide trihydrochloride

Hippuryl-Arg carboxypeptidase substrate

Sigma-Aldrich

H2508

Hippuryl-Arg

N-Benzoyl-Phe-Val-Arg-p-nitroanilide hydrochloride protease substrate

Sigma-Aldrich

B7632

N-Benzoyl-Phe-Val-Arg-p-nitroanilide hydrochloride

assay

≥98% (TLC)

assay

≥99% (HPLC)

assay

≥98% (TLC)

assay

≥98% (TLC)

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

solubility

methanol: 20 mg/mL, clear, colorless to light yellow

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

form

powder

form

powder

form

powder

form

powder

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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