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M3445

Sigma-Aldrich

Magnolol

≥90% (HPLC), from plant

Synonim(y):

2,2′-Bichavicol, 5,5′-Diallyl-2,2′-biphenyldiol

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About This Item

Wzór empiryczny (zapis Hilla):
C18H18O2
Numer CAS:
528-43-8
Masa cząsteczkowa:
266.33
Numer MDL:
MFCD00016658
Kod UNSPSC:
12352100
Identyfikator substancji w PubChem:
24896843
NACRES:
NA.25

pochodzenie biologiczne

plant

Próba

≥90% (HPLC)

rozpuszczalność

ethanol: soluble 1 mg/mL
methanol: soluble 1.5 mg/mL

spektrum działania antybiotyku

Gram-negative bacteria
Gram-positive bacteria
fungi

Zastosowanie

metabolomics
vitamins, nutraceuticals, and natural products

Tryb działania

cell membrane | interferes

temp. przechowywania

2-8°C

ciąg SMILES

Oc1ccc(CC=C)cc1-c2cc(CC=C)ccc2O

InChI

1S/C18H18O2/c1-3-5-13-7-9-17(19)15(11-13)16-12-14(6-4-2)8-10-18(16)20/h3-4,7-12,19-20H,1-2,5-6H2

Klucz InChI

VVOAZFWZEDHOOU-UHFFFAOYSA-N

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Opis ogólny

Magnolol is a bioactive neolignan extracted from the root and stem bark of different Chinese herbal Magnolia trees. It has a hydroxylated bi-phenoid structure like that of its structural isomer honokiol. It is a lipophilic compound.

Zastosowanie

Magnolol has been used:
  • to test its effect on muscle atrophy and macrophage subtypes in sarcopenia mouse model
  • to test its inhibitory effect on human umbilical vein endothelial cells (HUVECs) in angiogenesis assay
  • to test its anti-fungal effects on growth, ultrastructure, and biofilm formation of Candida spp. strains
  • in the preparation of immobilized amino-functionalized mesoporous silica particles for prolonged-release studies

Działania biochem./fizjol.

Magnolol exerts anti-depressant and, neurodegenerative properties. It is also considered to be a potent anti-cancer agent for its involvement in reducing cell proliferation, cell cytotoxicity, and inducing apoptosis.
Magnolol is a bioactive plant component isolated from the root and stem bark of Magnolia officinalis with antifungal, antibacterial and antioxidant effects. Magnolol also demonstrates anti-inflammatory activity by interferring with NF-κB signaling. It also appears to have anti-inflammatory properties related to vascular disorders such as atherosclerosis due to its ability to inhibit IL-6-induced STAT3 activation.

Hasło ostrzegawcze

Danger

Zwroty wskazujące rodzaj zagrożenia

H315,H318,H335,H411

Zwroty wskazujące środki ostrożności

P273 - P280 - P302 + P352 - P305 + P351 + P338 + P310

Klasyfikacja zagrożeń

Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

Organy docelowe

Respiratory system

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Środki ochrony indywidualnej

dust mask type N95 (US), Eyeshields, Gloves

Certyfikaty analizy (CoA)

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Development of a prolonged-release drug delivery system with magnolol loaded in amino-functionalized mesoporous silica
Stefanache A, et al.,
Applied Sciences, 237-237 (2017)
Hanna Kuk et al.
Scientific reports, 7(1), 17820-17820 (2017-12-21)
Due to gravity the venous vasculature in the lower extremities is exposed to elevated pressure levels which may be amplified by obesity or pregnancy. As a consequence, venules dilate and may be slowly transformed into varicose or spider veins. In
Jawad Behbehani et al.
Microbial pathogenesis, 113, 209-217 (2017-10-28)
The incidence of oral candidosis has increased in recent years due to the escalation in HIV-infection, cancer treatments, organ transplantation, and diabetes. In addition, corticosteroid use, dentures, and broad-spectrum antibiotic use have also contributed to the problem. Treatment of oral
Rajendra Karki et al.
Experimental cell research, 319(20), 3238-3250 (2013-08-03)
Increased proliferation and migration of vascular smooth muscle cells (VSMCs) contribute importantly to the formation of both atherosclerotic and restenotic lesions. The objective of this study was to investigate the effect of magnolol on VSMC migration. The proteolytic activity of
Abhishek Manoj Ranaware et al.
International journal of molecular sciences, 19(8) (2018-08-15)
The past few decades have witnessed widespread research to challenge carcinogenesis; however, it remains one of the most important health concerns with the worst prognosis and diagnosis. Increasing lines of evidence clearly show that the rate of cancer incidence will
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