G8044

Anti-phospho-GATA4 (pSer¹⁰⁵) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• UNSPSC Code: 12352203
• NACRES: NA.41
• MDL number: MFCD06798487
• Conjugate: unconjugated
• Clone: polyclonal
• Application: WB
• Citations: 2

Properties

• biological source: rabbit
• Quality Segment: 200
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 46 kDa
• species reactivity: mouse
• packaging: pkg of (1 vl = 100ul)
• technique(s): western blot: 1:500
• UniProt accession no.: Q08369
• shipped in: dry ice
• storage temp.: −70°C
• target post-translational modification: phosphorylation (pSer105; pSer105)
• Gene Information: human ... GATA4(2626) ; mouse ... Gata4(14463) ; rat ... Gata4(54254)

Description

Immunogen

Anti-phospho-GATA4 (pSer¹⁰⁵) antibody produced in rabbit is suitable for western blotting at working dilution 1:500.

synthetic phosphopeptide derived from the region of GATA-4 that contains serine 105.

Biochem/physiol Actions

GATA-4 has a molar mass of 46kDa and belongs to the GATA family of zinc finger-containing transcription factors. It is involved in the development of cardiac hypertrophy and remodeling. It plays a crucial role in regulating basal and agonist or stress-induced gene expression in cardiac and smooth muscle cell types. Upon agonist stimulation via MEK1-ERK1/2, and weakly via JNK or p38 MAPKs, Ser¹⁰⁵ of GATA-4 is phosphorylated. Phosphorylation of GATA-4 by hepatocyte growth factor facilitates cell survival in cardiac muscle cells via MEK/ERK-dependent signaling pathway.

Physical form

Solution in Dulbecco′s PBS, pH 7.3 with 1 mg/mL BSA and 0.05% Sodium Azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids