E7159

Exo2

Name: Exo2
Brand: SIGMA
Price: 369.75 PLN

≥98% (HPLC)

Synonim(y):

2-Methoxy-4-[(5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-4-yl)-hydrazonomethyl]-phenol

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5 MG

369,75 zł

Cena katalogowa435,00 złZaoszczędź 15%

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Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):

C₁₈H₁₈N₄O₂S

Numer CAS:

304684-77-3

Masa cząsteczkowa:

354.43

NACRES:

NA.77

PubChem Substance ID:

329799006

UNSPSC Code:

12352200

MDL number:

MFCD00380179

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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InChI

1S/C18H18N4O2S/c1-24-14-8-11(6-7-13(14)23)9-21-22-17-16-12-4-2-3-5-15(12)25-18(16)20-10-19-17/h6-10,23H,2-5H2,1H3,(H,19,20,22)/b21-9+

SMILES string

COc1cc(ccc1O)\C=N\Nc2ncnc3sc4CCCCc4c23

InChI key

VFNUTEMVQGLDAG-ZVBGSRNCSA-N

assay

≥98% (HPLC)

form

powder

color

yellow

solubility

DMSO: >20 mg/mL

storage temp.

2-8°C

Quality Level

100

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Ta pozycja	X3004	SML1741	SML1419
Sigma-Aldrich E7159 Exo2	Sigma-Aldrich X3004 XAV939	Sigma-Aldrich SML1741 TH1020	Sigma-Aldrich SML1419 B32B3
form powder	form powder	form powder	form powder
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥95% (HPLC)	assay ≥95% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. room temp	storage temp. 2-8°C	storage temp. 2-8°C
solubility DMSO: >20 mg/mL	solubility DMSO: 5 mg/mL, clear	solubility DMSO: 3 mg/mL, clear (warmed)	solubility DMSO: 10 mg/mL, clear
color yellow	color white to beige	color white to beige	color light yellow to dark yellow

Biochem/physiol Actions

Exo2 acts as a chemical probe of intracellular transport.

Exo2 acts as a chemical probe of intracellular transport. Edxo2 has activities similar to Brefeldin A with membrane trafficking to the Golgi appartus, but appears more selective.

Exo2 is a bioactive small molecule that activates Golgi-endoplasmic reticulum (ER) fusion in mammals by distorting the Golgi apparatus. It prevents the release of secretory cargo from the ER. Exo2 do not modify the morphology of the trans-Golgi network (TGN).[1] It also inhibits the anterograde movement of vesicular stomatitis virus G (VSV G) glycoprotein, from ER to Golgi.[2]

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Klasa składowania

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Odwiedź Bibliotekę dokumentów

Combined targeting of Arf1 and Ras potentiates anticancer activity for prostate cancer therapeutics.

Liwei Lang et al.

Journal of experimental & clinical cancer research : CR, 36(1), 112-112 (2017-08-24)

Although major improvements have been made in surgical management, chemotherapeutic, and radiotherapeutic of prostate cancer, many prostate cancers remain refractory to treatment with standard agents. Therefore, the identification of new molecular targets in cancer progression and development of novel therapeutic

Transcriptome Analysis and Identification of a Transcriptional Regulatory Network in the Response to H2O2.

Ayaka Hieno et al.

Plant physiology, 180(3), 1629-1646 (2019-05-09)

Hydrogen peroxide (H2O2) is a common signal molecule initiating transcriptional responses to all the known biotic and abiotic stresses of land plants. However, the degree of involvement of H2O2 in these stress responses has not yet been well studied. Here

The secretion inhibitor Exo2 perturbs trafficking of Shiga toxin between endosomes and the trans-Golgi network.

Robert A Spooner et al.

The Biochemical journal, 414(3), 471-484 (2008-06-05)

The small-molecule inhibitor Exo2 {4-hydroxy-3-methoxy-(5,6,7,8-tetrahydrol[1]benzothieno[2,3-d]pyrimidin-4-yl)hydraz-one benzaldehyde} has been reported to disrupt the Golgi apparatus completely and to stimulate Golgi-ER (endoplasmic reticulum) fusion in mammalian cells, akin to the well-characterized fungal toxin BFA (brefeldin A). It has also been reported that

RecQ Helicases Function in Development, DNA Repair, and Gene Targeting in Physcomitrella patens.

Gertrud Wiedemann et al.

The Plant cell, 30(3), 717-736 (2018-03-09)

RecQ DNA helicases are genome surveillance proteins found in all kingdoms of life. They are characterized best in humans, as mutations in RecQ genes lead to developmental abnormalities and diseases. To better understand RecQ functions in plants we concentrated on

Genome-Wide Reinforcement of DNA Methylation Occurs during Somatic Embryogenesis in Soybean.

Lexiang Ji et al.

The Plant cell, 31(10), 2315-2331 (2019-08-24)

Somatic embryogenesis is an important tissue culture technique that sometimes leads to phenotypic variation via genetic and/or epigenetic changes. To understand the genomic and epigenomic impacts of somatic embryogenesis, we characterized soybean (Glycine max) epigenomes sampled from embryos at 10

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Exo2