C9979

Monoclonal Anti-CD152 antibody produced in mouse

~1 mg/mL, clone AS32, purified immunoglobulin, buffered aqueous solution

• Synonym(s): Anti-CTLA-4
• UNSPSC Code: 12352203
• NACRES: NA.41
• MDL number: MFCD01864928
• Conjugate: unconjugated
• Clone: AS32, monoclonal
• Application: Neutral, WB
• Citations: 4

Properties

• biological source: mouse
• Quality Segment: 200
• conjugate: unconjugated
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: AS32, monoclonal
• form: buffered aqueous solution
• species reactivity: human
• concentration: ~1 mg/mL
• technique(s): neutralization: suitable, western blot: suitable
• isotype: IgG1
• UniProt accession no.: P16410
• shipped in: wet ice
• storage temp.: 2-8°C
• target post-translational modification: unmodified
• Gene Information: human ... CTLA4(1493)

Description

General description

CD152 is structurally similar to CD28 and is a member of the immunoglobin (Ig) gene superfamily. The gene encoding human CD152 is present on chromosone 2. It is composed of a single Ig V-like extracellular domain, a transmembrnne domain, and an intracellular domain. It is mainly expressed by cytotoxic T lymphocytes and the level of expression is activation-dependent.

CD152, a cell surface glycoprotein, is one of two ligands (the other is CD28) for CD80 (B7-1) and CD86 (B7-2). This interaction appears to function as a negative regulator to T cell activation. CD152 is transiently expressed on activated T cells.

Immunogen

recombinant extracellular domain of human CD152.

Application

Monoclonal Anti-CD152 antibody produced in mouse is suitable for western blotting and for neutralization studies, where this antibody has been shown to block the interaction of soluble human CD152 with human CD80.

Biochem/physiol Actions

CD152 and CD28 together with their ligands constitute one of the dominant co-stimulatory pathways that regulate T- and B-cell responses. CD152 acts as a co-stimulatory molecule in eliciting T cell help during antigen presentation and functions as a negative regulator of T cell activation.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 0.08% sodium azide.

Preparation Note

Prepared from tissue culture supernatant, purified using protein G.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable