C7270

Cefamandole nafate

~95%

• Synonym(s): Cefamandole formate sodium salt
• Linear Formula: C₁₉H₁₇N₆O₆S₂Na
• CAS Number: 42540-40-9
• Molecular Weight: 512.49
• UNSPSC Code: 51101500
• PubChem Substance ID: 24892951
• EC Number: 255-877-4
• MDL number: MFCD00864877

Properties

• assay: ~95%
• mode of action: cell wall synthesis | interferes
• SMILES string: [Na+].Cn1nnnc1SCC2=C(N3C(SC2)[C@H](NC(=O)[C@H](OC=O)c4ccccc4)C3=O)C([O-])=O
• InChI: 1S/C19H18N6O6S2.Na/c1-24-19(21-22-23-24)33-8-11-7-32-17-12(16(28)25(17)13(11)18(29)30)20-15(27)14(31-9-26)10-5-3-2-4-6-10;/h2-6,9,12,14,17H,7-8H2,1H3,(H,20,27)(H,29,30);/q;+1/p-1/t12-,14-,17-;/m1./s1
• InChI key: ICZOIXFFVKYXOM-YCLOEFEOSA-M

Description

General description

Chemical structure: β-lactam

Application

Cefamandole is used to study the effects of expression and inhibition of PBP 2A and other penicillin-binding proteins (PDPs) on bacterial cell wall mucopeptide synthesis.

Biochem/physiol Actions

Cefamandole nafate inhibits bacterial cell wall synthesis by inhibiting PBP 2A and other penicillin-binding proteins. Cefamandole nafate has been shown to be rapidly converted to cefamandolein bacteriological media .

Physical form

sodium carbonate: approx. 5%

Safety Information

• pictograms: GHS08,GHS07
• signalword: Danger
• hcodes: H315,H317,H319,H334,H335
• pcodes: P261 - P280 - P305 + P351 + P338 - P342 + P311
• Hazard Classifications: Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Storage Class: 13 - Non Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves