C197

8-(3-Chlorostyryl)caffeine

≥98% (HPLC), solid

• Synonim(y): 1,3,7-Trimethyl-8-(3-chlorostyryl)xanthine, CSC
• Wzór empiryczny (zapis Hilla): C₁₆H₁₅ClN₄O₂
• Numer CAS: 147700-11-6
• Masa cząsteczkowa: 330.77
• NACRES: NA.77
• PubChem Substance ID: 24277703
• UNSPSC Code: 12352200
• MDL number: MFCD00210188
• Assay: ≥98% (HPLC)
• Form: solid
• Quality level: 100

Właściwości

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: solid
• color: white
• solubility: DMSO: >5 mg/mL
• storage temp.: −20°C
• SMILES string: [H]\C(=C(\[H])c1nc2C(=O)N(C)C(=O)N(C)c2n1C)c3cccc(Cl)c3
• InChI: 1S/C16H15ClN4O2/c1-19-12(8-7-10-5-4-6-11(17)9-10)18-13-14(19)20(2)16(23)21(3)15(13)22/h4-9H,1-3H3/b8-7+
• InChI key: MHYRUZOJQQLLQS-BQYQJAHWSA-N
• Gene Information: human ... ADORA2A(135) ; mouse ... Maob(109731) ; rat ... Adora1(29290), Adora2a(25369)

Opis

Application

8-(3-Chlorostyryl)caffeine has been used as an adenosine A_2A receptor antagonist:

• to study its effects on levodopa (L-DOPA)-induced dopamine (DA) release in rat striatum[1]
• to study its effect on the nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) activity in macrophages[2]
• to determine its effects on human umbilical vein endothelial cells (HUVECs)[3]

Biochem/physiol Actions

8-(3-Chlorostyryl)caffeine is a selective adenosine A_2A receptor antagonist[1] and monoamine oxidase B (MAO B) inhibitor.[4]

Features and Benefits

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Disclaimer

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)