B2938

BEPP monohydrochloride

≥98% (HPLC), PKR activator, powder

• Synonim(y): 1H-Benzimidazole-1-ethanol, 2,3-dihydro-2-imino-alpha-(phenoxymethyl)-3-(phenylmethyl)- monohydrochloride
• Wzór empiryczny (zapis Hilla): C₂₃H₂₃N₃O₂ HCl
• Numer CAS: 455311-98-5
• Masa cząsteczkowa: 409.91
• UNSPSC Code: 12352200
• PubChem Substance ID: 329773209
• NACRES: NA.77
• MDL number: MFCD00964481
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Właściwości

• Nazwa produktu: BEPP monohydrochloride, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to off-white
• solubility: DMSO: >10 mg/mL
• storage temp.: 2-8°C
• SMILES string: Cl.OC(COc1ccccc1)CN2C(=N)N(Cc3ccccc3)c4ccccc24
• InChI: 1S/C23H23N3O2.ClH/c24-23-25(15-18-9-3-1-4-10-18)21-13-7-8-14-22(21)26(23)16-19(27)17-28-20-11-5-2-6-12-20;/h1-14,19,24,27H,15-17H2;1H
• InChI key: KDMXJFUGIDGZQL-UHFFFAOYSA-N

Opis

Biochem/physiol Actions

BEPP is a double-strand RNA-dependent protein kinase (PKR) activator.

BEPP is a double-strand RNA-dependent protein kinase (PKR) activator. The double-strand RNA (dsRNA)-dependent protein kinase is a ubiquitously expressed serine threonine kinase, inducible by interferon γ. PRK is involved in several curtail cellular regulations including phosphorylation of eIF2α (which leads to inhibition of protein synthesis and eliciting antivirus and antitumor activities), modulating activities of eIF2α, NF-κB, ATF-3, and p53. BEPP also inhibits the growth of a human lung cancer cell line overexpressing PKR.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable