A6476

ABT-418 hydrochloride

powder, ≥98% (HPLC)

• Synonym(s): 3-Methyl-5-[(2S)-1-methyl-2-pyrrolidinyl]isoxazole hydrochloride
• Empirical Formula (Hill Notation): C₉H₁₄N₂O · HCl
• CAS Number: 147388-83-8
• Molecular Weight: 202.68
• NACRES: NA.77
• PubChem Substance ID: 24724395
• UNSPSC Code: 51111800
• MDL number: MFCD11045960
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Properties

• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• solubility: H₂O: soluble 15 mg/mL
• originator: Abbott
• SMILES string: Cl.CN1CCC[C@H]1c2cc(C)no2
• InChI: 1S/C9H14N2O.ClH/c1-7-6-9(12-10-7)8-4-3-5-11(8)2;/h6,8H,3-5H2,1-2H3;1H/t8-;/m0./s1
• InChI key: VOXHERKWAIEJQF-QRPNPIFTSA-N

Description

General description

ABT-418 is an α4β2 agonist of nicotinic receptors.[1]

Application

ABT-418 [(S)-3-methyl-5-(1 methyl-2-pyrrolidinyl)isoxazole hydrochloride] is a novel neuronal nicotinic acetylcholine receptor (nAChR) ligand with cognitive enhancing and anxiolytic-like activity 3- to 10-fold more potent than (-)-nicotine in rodents. ABT-418 hydrochloride has been used to study new therapeutic approaches for the treatment of Alzheimer′s disease.

ABT-418 hydrochloride has been used as a nicotinic acetylcholine receptor (nAChR) agonist to test its effect on spatial memory improvement in attention deficit hyperactivity disorder (ADHD) rat model[2]

Biochem/physiol Actions

Neuronal nicotinic acetylcholine receptor agonist with cognition enhancing and anxiolytic activities.

Features and Benefits

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Subject to U.S. Patent No. 5409946 and sold under license from Abbott Laboratories.

Safety Information

• pictograms: GHS06
• signalword: Danger
• hcodes: H300 + H310 + H330
• pcodes: P260 - P262 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310
• Hazard Classifications: Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable