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S0883

Sulfasalazine

97.0-101.5%

Synonim(y):

2-Hydroxy-5-{{4-[(2-pyridinylamino)sulfonyl]phenyl}azo}benzoic acid, 5-[4-(2-Pyridylsulfamoyl)phenylazo]salicylic acid, Salicylazosulfapyridine

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Gabaryty przesyłkiSKUDostępnośćCena netto
10 g
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305,00 zł

Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):
C18H14N4O5S
Numer CAS:
Masa cząsteczkowa:
398.39
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
209-974-3
Beilstein/REAXYS Number:
356241
MDL number:

305,00 zł


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Quality Segment

assay

97.0-101.5%

form

powder

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

mp

260-265 °C (dec.) (lit.)

application(s)

forensics and toxicology
pharmaceutical (small molecule)

mode of action

DNA synthesis | interferes, enzyme | inhibits

SMILES string

OC(=O)c1cc(ccc1O)\N=N\c2ccc(cc2)S(=O)(=O)Nc3ccccn3

InChI

1S/C18H14N4O5S/c23-16-9-6-13(11-15(16)18(24)25)21-20-12-4-7-14(8-5-12)28(26,27)22-17-3-1-2-10-19-17/h1-11,23H,(H,19,22)(H,24,25)/b21-20+

InChI key

NCEXYHBECQHGNR-QZQOTICOSA-N

Gene Information

General description

Chemical structure: sulfonamide
Sulfasalazine (SSZ) belongs to the sulfonamide class of drugs, which can be metabolized into 5-aminosalicylic acid and sulfapyridine. SSZ is obtained as a reaction product of an antibacterial agent (sulfapyridine) and an anti-inflammatory agent (salicylic acid).

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Sulfasalazine has been used as an analytical standard in clinical studies:
  • For investigating its therapeutic potential in patients suffering from multiple sclerosis (MS).[1]
  • For studying its role as an antiarthritic agent via inhibition of the cartilage degeneration and pain associated with progression of osteoarthritis in the rat, which is used as the test animal.

It may also be used as an analytical reference standard for the quantification of the analyte in biological samples and aqueous samples using enzyme-linked immunosorbent assay (ELISA) and spectrofluorimetic technique.



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Ta pozycja
PHR32431636005BP779
Sulfasalazine British Pharmacopoeia (BP) Reference Standard

BP779

Sulfasalazine

application(s)

forensics and toxicology
pharmaceutical (small molecule)

application(s)

pharmaceutical

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical
pharmaceutical small molecule

Gene Information

human ... ALOX5(240), PTGS1(5742), PTGS2(5743)

Gene Information

-

Gene Information

human ... ALOX5(240), PTGS1(5742), PTGS2(5743)

Gene Information

human ... ALOX5(240), PTGS1(5742), PTGS2(5743)

assay

97.0-101.5%

assay

-

assay

-

assay

-

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

technique(s)

-

technique(s)

-

form

powder

form

-

form

-

form

crystalline

Quality Level

200

Quality Level

300

Quality Level

-

Quality Level

-


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pictograms

Health hazardEnvironment

signalword

Danger

Hazard Classifications

Aquatic Chronic 2 - Carc. 2 - Repr. 2 - Resp. Sens. 1 - Skin Sens. 1

Klasa składowania

11 - Combustible Solids

wgk

WGK 2

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves



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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów



Irene E van der Horst-Bruinsma et al.
Annals of the rheumatic diseases, 72(7), 1221-1224 (2012-12-25)
To examine the impact (if any) of gender on the clinical, functional and patient-reported outcomes of treatment using data pooled from four controlled clinical trials. Study data were pooled from four clinical control trials in which 1283 adult patients with
Optimization of ionic liquid based dispersive liquid?liquid microextraction combined with dispersive micro-solid phase extraction for the spectrofluorimetric determination of sulfasalazine in aqueous samples by response surface methodology
Sadegh S and Oliaei S
Royal Society of Chemistry Advances, 6(114), 113551-113560 (2016)
Sushil Kumar et al.
The Cochrane database of systematic reviews, 10, CD008424-CD008424 (2012-10-19)
Ulcerative colitis (UC) is a chronic inflammatory condition of the colon characterized by episodes of disease activity and symptom-free remission.There is paucity of evidence regarding the efficacy and safety of complementary or alternative medicines for the management of UC. Curcumin



Numer pozycji handlu globalnego

SKUNUMER GTIN
S0883-100G04061833015247
S0883-50G04061833015261
S0883-10G04061836830915

Questions

1–4 of 4 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. What are the suitable solvents for Sulfasalazine (Sigma-Aldrich, S0883) and at what concentrations is it soluble.

    1 answer
    1. This product is soluble at 50 mg/mL in 1 M Ammonium hydroxide, heating may be required. This material is insoluble in water, benzene, chloroform, and ether. The compound is reported soluble at a ratio of 1:2900 in ethanol, and 1:1500 in methanol, and is expected to be generally soluble in alkali hydroxides.

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  4. What is the powder color? Sulfasalazine is stable for how many time under the standard conditions (temperature around 25-celsius degree, protected from light)?

    1 answer
    1. The color of the powder is "Yellow to brown" as listed on the Certificate of Analysis. This product, in powdered format, should be stable for up to 7 years in room temperature.

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