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38370

DIC

≥98.0% (GC), for peptide synthesis

Synonim(y):

N,N′-Diisopropylcarbodiimide

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Gabaryty przesyłkiSKUDostępnośćCena netto
25 mL
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399,00 zł
100 mL
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1000,00 zł
500 mL
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3770,00 zł

Informacje o tej pozycji

Wzór liniowy:
(CH3)2CHN=C=NCH(CH3)2
Numer CAS:
Masa cząsteczkowa:
126.20
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352001
EC Number:
211-743-7
MDL number:
Beilstein/REAXYS Number:
878281

399,00 zł


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Nazwa produktu

DIC, purum, ≥98.0% (GC)

grade

purum

Quality Level

assay

≥98.0% (GC)

form

liquid

reaction suitability

reaction type: Coupling Reactions

refractive index

n20/D 1.433 (lit.)

bp

145-148 °C (lit.)

density

0.815 g/mL at 20 °C

application(s)

peptide synthesis

functional group

amine

SMILES string

CC(C)N=C=NC(C)C

InChI

1S/C7H14N2/c1-6(2)8-5-9-7(3)4/h6-7H,1-4H3

InChI key

BDNKZNFMNDZQMI-UHFFFAOYSA-N

Gene Information

human ... EPHX2(2053)
mouse ... Ephx2(13850)

General description

N,N′-Diisopropylcarbodiimide (DIC) is a carbodiimide used as a coupling reagent in the synthesis of amides, peptides, ureas, heterocycles, and unsymmetrical carbodiimides. It is also used in the polymerization reactions as an activator.

Application

N,N′-Diisopropylcarbodiimide can be used:
  • To synthesize lanthanide (Ln) guanidinate complexes via insertion of carbodiimide into the Ln-N bond of lanthanocene secondary amido complexes.
  • To facilitate the cyclization of N-(β-Hydroxy)amides to form 2-oxazolines.
  • To synthesize 1-isopropyl-2-alkoxycarbonyl-3-isopropyliminio-aziridine by reacting with alkyl diazoacetates in the presence of transition metal salts.

DIC can be used as:
  • A coupling reagent for the synthesis of various esters and amides by treating carboxylic acids with phenols and amines respectively.
  • A reagent for the conversion of alcohols to aldehydes or ketones in the presence of DMSO via modified Moffatt-type oxidation reaction.
  • A reagent to facilitates the preparation of alkyl halides from corresponding alcohols via the formation of o-alkylisourea.[1]

Alternative to dicyclohexylcarbodiimide in peptide synthesis.
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Ta pozycja
D12540736650D80002
DIC purum, ≥98.0% (GC)

Sigma-Aldrich

38370

DIC

DCC puriss., ≥99.0% (GC)

Sigma-Aldrich

36650

DCC

DCC 99%

Sigma-Aldrich

D80002

DCC

grade

purum

grade

-

grade

puriss.

grade

-

form

liquid

form

liquid

form

solid

form

solid

assay

≥98.0% (GC)

assay

99%

assay

≥99.0% (GC)

assay

99%

functional group

amine

functional group

-

functional group

-

functional group

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

refractive index

n20/D 1.433 (lit.)

refractive index

n20/D 1.433 (lit.)

refractive index

-

refractive index

-


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Danger

Hazard Classifications

Acute Tox. 1 Inhalation - Eye Dam. 1 - Flam. Liq. 3 - Resp. Sens. 1 - Skin Sens. 1

Klasa składowania

3 - Flammable liquids

wgk

WGK 3

flash_point_f

91.4 °F

flash_point_c

33 °C

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter



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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów



Insertion of a carbodiimide into the Ln? N ?-bond of organolanthanide complexes. Isomerization and rearrangement of organolanthanides containing guanidinate ligands.
Zhang J
Organometallics, 23(13), 3303-3308 (2004)
1, 3-Diisopropylcarbodiimide
Nora GP, et al.
Encyclopedia of Reagents for Organic Synthesis, Second Edition (2001)
Amidation and esterification of carboxylic acids with amines and phenols by N, N?-diisopropylcarbodiimide: A new approach for amide and ester bond formation in water
Fattahi N, et al.
Tetrahedron, 74(32), 4351-4356 (2018)



Numer pozycji handlu globalnego

SKUNUMER GTIN
38370-25ML04061831964738
38370-100ML04061831964516
38370-500ML04061831964752

Questions

1–3 of 3 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  3. hi, what is the concentration of this product?

    1 answer
    1. The concentration of this product can be determined using the lot specific purity reported in the Certificate of Analysis, the density, and the compound molecular weight. This product has a density of 0.815 g/mL and a molecular weight of 126.20 g/mol. The minimum purity is 98.0%, thus the molarity will vary slightly from lot to lot. The molarity can range from 6.33M (98.0%) to 6.46M (100%).

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