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37094

Rapamycin

VETRANAL®, analytical standard

Synonim(y):

Sirolimus

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Gabaryty przesyłkiSKUDostępnośćCena netto
10 mg
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2070,00 zł

Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):
C51H79NO13
Numer CAS:
Masa cząsteczkowa:
914.17
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:

2070,00 zł


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grade

analytical standard

Quality Segment

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

storage temp.

−20°C

SMILES string

CO[C@@H]1C[C@@H](CC[C@H]1O)C[C@@H](C)[C@@H]2CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C[C@@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N4CCCC[C@H]4C(=O)O2)OC

InChI

1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1

InChI key

QFJCIRLUMZQUOT-HPLJOQBZSA-N

Gene Information

human ... FKBP1A(2280)

General description

Rapamycin belongs to the macrolide class of antibiotics obtained from the bacterium Streptomyces hygroscopicus. It was first used as an anti-fungal agent but later also found use as an immunosuppressant and potential anti-cancer drug. It acts by preventing the activity of serine/threonine kinase and subsequently blocking the cytokine-driven T cell proliferation.

Application

The analytical standard can be used as follows:
  • Electrochemical determination of rapamycin using boron-doped diamond electrode and differential pulse voltammetry (DPV) in human urine, serum, and blood samples
  • Simultaneous determination of six immunosuppressants from whole blood samples by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) technique combined with modified QuEChERS method

Other Notes

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
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Ta pozycja
553210R8781R0395
Rapamycin VETRANAL®, analytical standard

Supelco

37094

Rapamycin

grade

analytical standard

grade

-

grade

-

grade

-

format

neat

format

-

format

-

format

-

shelf life

limited shelf life, expiry date on the label

shelf life

-

shelf life

-

shelf life

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

application(s)

forensics and toxicology
pharmaceutical (small molecule)

application(s)

-

application(s)

-

application(s)

-

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

technique(s)

-

technique(s)

-


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pictograms

Health hazard

signalword

Warning

Hazard Classifications

Carc. 2 - Repr. 2

Klasa składowania

11 - Combustible Solids

wgk

WGK 2



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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów



Complications in Surgery (2006)
Xing Liu et al.
Journal of virology, 93(17) (2019-06-14)
The Us11 protein encoded by herpes simplex virus 1 (HSV-1) functions to impair autophagy; however, the molecular mechanisms of this inhibition remain to be fully established. Here, we report that the Us11 protein targets tripartite motif protein 23 (TRIM23), which
B cell activating factor (BAFF) selects IL-10? B cells over IL-10+ B cells during inflammatory responses
Ma N, et al.
Molecular Immunology, 85, 18-26 (2017)



Numer pozycji handlu globalnego

SKUNUMER GTIN
37094-10MG04061831833744

Questions

1–3 of 3 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. How does one take this product? Ingestion or injection?

    1 answer
    1. This product is intended for use as an analytical standard and may not be used for therapeutic or diagnostic purposes for humans or animals.

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