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04725
3-Hydroxyglutaric acid
analytical standard
Synonim(y):
β-Hydroxyglutaric acid, 3-Hydroxypentanedioic acid
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| Gabaryty przesyłki | SKU | Dostępność | Cena netto |
|---|---|---|---|
| 10 mg | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 952,00 zł | |
| 50 mg | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 4360,00 zł |
Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C5H8O5
Numer CAS:
Masa cząsteczkowa:
148.11
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
12352106
MDL number:
Beilstein/REAXYS Number:
1705476
952,00 zł
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
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Pozwól nam pomócgrade
analytical standard
Quality Level
assay
≥95.0% (GC)
shelf life
limited shelf life, expiry date on the label
application(s)
clinical testing
format
neat
storage temp.
2-8°C
InChI
1S/C5H8O5/c6-3(1-4(7)8)2-5(9)10/h3,6H,1-2H2,(H,7,8)(H,9,10)
InChI key
ZQHYXNSQOIDNTL-UHFFFAOYSA-N
Biochem/physiol Actions
3-Hydroxyglutaric acid is a glutaric acid derivative which is the byproduct of glutaric acidemia type I. Glutaric aciduria type I (glutaryl-CoA dehydrogenase deficiency) is an inborn error of metabolism that usually manifests in infancy by an acute encephalopathic crisis and often results in permanent motor handicap. Studies indicate that 3-hydroxyglutaric acid can be used as biomarker for GCDH (glutaryl-CoA dehydrogenase) deficiency. It is believed that the excretion of 3-hydroxyglutaric acid is increased during ketosis, which occurs during glutaryl-CoA dehydrogenase deficiency. Studies on striatal cultures show that IGF-1 and FGF-2 (bFGF) reduces 3-hydroxyglutaric acid toxicity in striatal neurons.
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
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Ta pozycja | |||
|---|---|---|---|
| format neat | format - | format - | format - |
| grade analytical standard | grade - | grade analytical standard | grade - |
| Quality Level 100 | Quality Level 200 | Quality Level - | Quality Level 100 |
| application(s) clinical testing | application(s) cell analysis | application(s) - | application(s) - |
| assay ≥95.0% (GC) | assay ≥95% (GC) | assay ≥98.0% (GC) | assay ≥97.0% |
| shelf life limited shelf life, expiry date on the label | shelf life - | shelf life limited shelf life, expiry date on the label | shelf life - |
Klasa składowania
11 - Combustible Solids
wgk
WGK 3
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Garfield A Simon et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1097-1098, 101-110 (2018-09-16)
Glutaric aciduria type 1, a deficiency of glutaryl-CoA dehydrogenase, causes an accumulation of neurotoxic metabolites glutaric acid and 3-hydroxyglutaric acid (3-HGA). Testing of these analytes is routinely done by GC-MS but seldom account for interference from isomers or compounds with
Gustavo C Ferreira et al.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 25(6), 391-398 (2007-07-24)
Glutaric acidemia type I is an inherited metabolic disorder caused by a severe deficiency of the mitochondrial glutaryl-CoA dehydrogenase activity leading to accumulation of predominantly glutaric and 3-hydroxyglutaric acids in the brain tissue of the affected patients. Considering that a
Paris Jafari et al.
PloS one, 8(1), e53735-e53735 (2013-01-18)
Glutaric aciduria type I (glutaryl-CoA dehydrogenase deficiency) is an inborn error of metabolism that usually manifests in infancy by an acute encephalopathic crisis and often results in permanent motor handicap. Biochemical hallmarks of this disease are elevated levels of glutarate
Numer pozycji handlu globalnego
| SKU | NUMER GTIN |
|---|---|
| 04725-10MG | 04061838635709 |
| 04725-50MG | 04061838635716 |