5.33872

miR-122 Inhibitor, NSC5476

• Synonim(y): 6-[(4a R,8a S)-(oktahydrochinolin-1(2H)-ylsulfonylo)-1,2,3,4-tetrahydrochinolina, NSC-5476, MLS000736518, microRNA-122 Inhibitor, 6-[(4a R,8a S)-(oktahydro-1(2H)-chinolinylsulfonylo)-1,2,3,4-tetrahydrochinolina, pri-miR-122 Tran
• Wzór empiryczny (zapis Hilla): C₁₈H₂₆N₂O₂S
• Numer CAS: 5455-90-3
• Masa cząsteczkowa: 334.48
• Numer MDL: MFCD30559255
• Kod UNSPSC: 12352200
• NACRES: NA.77

Właściwości

• Próba: ≥98% (HPLC)
• Poziom jakości: 100
• Formularz: solid
• producent / nazwa handlowa: Calbiochem^®
• warunki przechowywania: OK to freeze
• kolor: white
• rozpuszczalność: DMSO: 50 mg/mL
• temp. przechowywania: 2-8°C
• ciąg SMILES: [S](=O)(=O)(N3[C@@H]4[C@@H](CCC3)CCCC4)c1cc2c(cc1)NCCC2
• InChI: 1S/C18H26N2O2S/c21-23(22,16-9-10-17-15(13-16)6-3-11-19-17)20-12-4-7-14-5-1-2-8-18(14)20/h9-10,13-14,18-19H,1-8,11-12H2/t14-,18+/m1/s1
• Klucz InChI: LECPJKATPJRAMB-KDOFPFPSSA-N

Opis

Opis ogólny

A cell-permeable trans-decahydroquinolinylsulfonamide compound that acts as a potent, selective, and reversible inhibitor of miR-122 (EC₅₀ = 600 nM in Huh7 cells transfected with psiCHECK-miR122 reporter plasmid). Induces a 1,250% increase in the relative luciferase signal that is indicative of strong miRNA-122 inhibition. Displays very little activity towards miR-21. Shown to down regulate the levels of mature miR-122 (by 72%) and the primary miR-122 (down to 3%). Shown to reduce hepatitis C virus (HCV) replication in Huh7 cells (47% reduction at 10 µM).

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

Działania biochem./fizjol.

Cell permeable: yes

Primary Target
miR-122

Reversible: yes

Opakowanie

Packaged under inert gas

Ostrzeżenie

Toxicity: Standard Handling (A)

Rekonstytucja

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Inne uwagi

Young, D.D., et al. 2010. J. Am. Chem. Soc.132, 7976.

Connelly, C.M., et al. 2012. J. Biomol. Screen.17, 822.

Informacje prawne

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable