525276

Phosphoramidon, Disodium Salt

Inhibits some metalloendopeptidases.

• Synonim(y): Phosphoramidon, Disodium Salt, N-(α-Rhamnopyranosyloxyhydroxyphosphinyl)-L-leucyl-L-tryptophan, 2Na
• Wzór empiryczny (zapis Hilla): C₂₃H₃₂N₃O₁₀P · 2Na
• Masa cząsteczkowa: 587.47
• NACRES: NA.77
• UNSPSC Code: 12352202
• Form: lyophilized solid
• Storage condition: OK to freeze, desiccated (hygroscopic), protect from light

Właściwości

• Quality Segment: 100
• form: lyophilized solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated (hygroscopic), protect from light
• color: white
• solubility: DMSO: 10 mg/mL, methanol: soluble, water: soluble
• shipped in: ambient
• storage temp.: 2-8°C

Opis

General description

Effective concentration: 1-10 µM.

Inhibits some metalloendopeptidases. Highly specific inhibitor of thermolysin. Inhibits the conversion of big endothelin-1 to endothelin (IC₅₀ = 4.6 µM).

Biochem/physiol Actions

Cell permeable: no

Primary Target
thermolysin

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 4.6 µM against the conversion of big endothelin-1 to endothelin

Analysis Note

Single spot by TLC

Other Notes

Balwierczxak, J.L., et al. 1995. Biochem. Pharmacol. 49, 291.
Howell, S., et al. 1993. Biochem. J. 290, 159.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable