517301

P-Glycoprotein Inhibitor, C-4

The P-Glycoprotein Inhibitor, C-4 controls the biological activity of P-Glycoprotein. This small molecule/inhibitor is primarily used for Cancer applications.

• Synonim(y): P-Glycoprotein Inhibitor, C-4, (E)-4-Chloro-N-(3-(3-(4-hydroxy-3-methoxyphenyl)acryloyl)phenyl)benzamide, C-4
• Wzór empiryczny (zapis Hilla): C₂₃H₁₈ClNO₄
• Numer CAS: 864426-22-2
• Masa cząsteczkowa: 407.85
• UNSPSC Code: 12352202
• NACRES: NA.77
• PubChem Substance ID: 16062976
• Assay: ≥95% (HPLC)
• Form: solid
• Storage condition: OK to freeze, protect from light

Właściwości

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: yellow
• solubility: DMSO: 10 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: COC1=C(C=CC(=C1)C=CC(=O)C2=CC(=CC=C2)NC(=O)C3=CC=C(C=C3)Cl)O
• InChI: 1S/C23H18ClNO4/c1-29-22-13-15(6-12-21(22)27)5-11-20(26)17-3-2-4-19(14-17)25-23(28)16-7-9-18(24)10-8-16/h2-14,27H,1H3,(H,25,28)
• InChI key: SFYVLZRWJCFMTJ-UHFFFAOYSA-N

Opis

General description

A cell-permeable cinnamoyl compound that reversibly inhibits P-gp (P-glycoprotein) efflux function and reverses the MDR (multidrug resistance) phenotype with no noticeable effect on P-gp expression. Shown to significantly enhance Paclitaxel- (Cat. No. 580555) and Vincristine- (Cat. No. 677181) induced cytotoxicity as well as apoptosis in P-gp expressing KBV20C cells.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
P-Glycoprotein

Product does not compete with ATP.

Reversible: yes

Packaging

Packaged under inert gas

Other Notes

Kim, Y.K., et al. 2007. Biochem. Biophys. Res. Commun.355, 136.
Woo, H.B., et al. 2005. Bioorg. Med. Chem. Lett.15, 3782.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable