481412

NF-kB Activation Inhibitor IV

The NF-kB Activation Inhibitor IV, also referenced under CAS 139141-12-1, controls the biological activity of NF-kB. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

• Synonim(y): NF-kB Activation Inhibitor IV, (E)-2-Fluoro-4ʹ-methoxystilbene
• Wzór empiryczny (zapis Hilla): C₁₅H₁₃FO
• Numer CAS: 139141-12-1
• Masa cząsteczkowa: 228.26
• MDL number: MFCD12912333
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: crystalline solid
• Storage condition: OK to freeze, protect from light

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: crystalline solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• solubility: DMSO: 20 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: Fc1c(cccc1)\C=C\c2ccc(cc2)OC
• InChI key: ILVFNAZMSMNXJG-RMKNXTFCSA-N

Opis

General description

A cell-permeable trans-stilbene Resveratrol (Cat. No. 554325) analog that exhibits much enhanced anti-inflammatory potency, but no anti-oxidant activity. Suppresses LPS-induced COX-2 mRNA expression in BV-2 cells (~46% inhibition at 150 nM) and Shown to be ~130-fold more potent than Resveratrol in inhibiting TNF-α-stimulated NF-κB reporter activity in 293T cells (IC₅₀ = 150 nM).

Biochem/physiol Actions

Product does not compete with ATP.

Reversible: no

Cell permeable: yes

Primary Target
NF-κB Activation

Target IC₅₀: 150 nM inhibiting TNF-α-stimulated NF-κB reporter activity in 293T cells.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Heynekamp, J.J., et al. 2006. J. Med. Chem.49, 7182.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable