218750

Caspase-3 Inhibitor III

The Caspase-3 Inhibitor III, also referenced under CAS 285570-60-7, controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications.

• Synonim(y): Caspase-3 Inhibitor III, Ac-DEVD-CMK
• Wzór empiryczny (zapis Hilla): C₂₁H₃₁ClN₄O₁₁
• Numer CAS: 285570-60-7
• Masa cząsteczkowa: 550.94
• MDL number: MFCD25372552
• UNSPSC Code: 12352200
• NACRES: NA.54
• Assay: ≥98% (HPLC)
• Form: lyophilized solid, powder
• Storage condition: OK to freeze, desiccated

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: lyophilized solid, powder
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated
• color: white to off-white
• solubility: 20% acetonitrile: 1 mg/mL
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: ClCC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)C)CC(=O)O)CCC(=O)O)C(C)C)CC(=O)O
• InChI: 1S/C21H31ClN4O11/c1-9(2)18(21(37)25-12(6-16(31)32)14(28)8-22)26-19(35)11(4-5-15(29)30)24-20(36)13(7-17(33)34)23-10(3)27/h9,11-13,18H,4-8H2,1-3H3,(H,23,27)(H,24,36)(H,25,37)(H,26,35)(H,29,30)(H,31,32)(H,33,34)/t11-,12-,13-,18-/m0/s1
• InChI key: ATNOUPFYBMVFLD-RSLFNQERSA-N

Opis

General description

A potent cell-permeable and irreversible inhibitor of caspase-3, a member of the ICE-CED-3 family of cysteine proteases.

A potent, cell-permeable, and irreversible inhibitor of caspase-3 as well as caspase-6, caspase-7, caspase-8, and caspase-10.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
caspase-3, caspase-6, caspase-7, caspase-8, caspase-10

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.

Other Notes

Ac-Asp-Glu-Val-Asp-CMK

Mocanu, M.M., et al. 2000. Br. J. Pharmacol.130, 197
Schrantz, N., et al. 1999. Cell Death Differ. 6, 445.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable