171264

Inhibitor AMPK, związek C-2HCl

InSolution, ≥98%

• Synonim(y): 6-(4-(2-piperydyn-1-ylo-etoksy)-fenylo)-3-pirydyn-4-ylopirazolo[1,5-a]pirymidyna, 2HCl, H₂O, Związek C, 2HCl, H₂O, Inhibitor AMPK I, Inhibitor AMPK I, 6-(4-(2-piperydyn-1-ylo-etoksy)-fenylo)-3-pirydyn-4-ylopirazolo[1,5-a]pirymidyna, 2HCl, H₂O, Związek C, 2HCl, H₂O, Inhibitor AMPK InSolution, związek C-2HCl
• Wzór empiryczny (zapis Hilla): C₂₄H₂₅N₅O
• Numer CAS: 866405-64-3
• Masa cząsteczkowa: 399.49
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD08705402
• Assay: ≥98% (HPLC)
• Form: liquid
• Storage condition: OK to freeze, protect from light

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: liquid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: [n]21ncc(c2ncc(c1)c4ccc(cc4)OCCN5CCCCC5)c3ccncc3
• InChI: 1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2
• InChI key: XHBVYDAKJHETMP-UHFFFAOYSA-N

Opis

General description

A cell-permeable pyrrazolopyrimidine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase; K_i = 109 nM in the presence of 5 µM ATP and the absence of AMP). Does not affect the activities of ZAPK, Syk, PKCθ, PKA, or JAK3. Blocks celluar activities induced by AICAr (Cat. No.123040) or Metformin (Cat. No. 317240). Induces weight loss by attenuating AMPK-mediated food intake in mice. The solid form of this compound (Cat. No. 171260) is also available.

Packaging

Packaged under inert gas

Physical form

A 10 mM (2 mg/408 µl) solution of AMPK Inhibitor, Compound C, 2HCl, (Cat. No. 171260) in H₂O.

Preparation Note

Following intial thaw, aliquot and freeze (-20°C).

Other Notes

Yu, P.B., et al. 2008. Nat. Chem. Biol4, 33.
Kim, E.K., et al. 2004. J. Biol. Chem.279, 19970.
Lee, M., et al. 2003. J. Biol. Chem.278, 39653.
Inoki, K., et al. 2003. Cell115, 577.
Fryer, L.G., 2002. FEBS Lett.531, 189.
Zhou, G., et al. 2001. J. Clin. Invest.108, 1167.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Ta strona może zawierać tekst przetłumaczony maszynowo.

Informacja o środkach bezpieczeństwa

• Klasa składowania: 12 - Non Combustible Liquids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable