- Cross dehydrogenative arylation (CDA) of a benzylic C-H bond with arenes by iron catalysis.
Cross dehydrogenative arylation (CDA) of a benzylic C-H bond with arenes by iron catalysis.
Angewandte Chemie (International ed. in English) (2009-04-18)
Yi-Zhou Li, Bi-Jie Li, Xing-Yu Lu, Song Lin, Zhang-Jie Shi
PMID19373817
ABSTRACT
Hooking up: FeCl(2) catalyzes the efficient cross dehydrogenative arylation of substrates having benzylic C-H bonds (see scheme). High regioselectivity was observed during the cross-coupling between compounds containing aromatic C(sp(2))-H bonds and benzylic C(sp(3))-H bonds. This process is proposed to proceed by single-electron-transfer oxidation and Friedel-Crafts alkylation.
MATERIALS