Skip to Content
Merck
  • Regioselective oxidation of 2-amino-3-aroyl-4,5-dialkylthiophenes by DMSO.

Regioselective oxidation of 2-amino-3-aroyl-4,5-dialkylthiophenes by DMSO.

Bioorganic & medicinal chemistry letters (2004-03-12)
Elizabeth Joshi, Mahendra D Chordia, Timothy L Macdonald, Joel Linden, Ray Olsson
PMID15012996
ABSTRACT

Solutions of 2-amino-3-aroyl-4,5-dialkylthiophenes in DMSO (dimethyl sulfoxide) undergo regioselective oxidation of benzylic carbon under mild conditions. We describe three examples and propose a mechanism for oxidation.