A labdane diterpene glucoside from the rhizomes of Curcuma mangga.

A labdane diterpene glucoside from the rhizomes of Curcuma mangga.

Journal of natural products (2005-07-26)

Faridah Abas, Nordin H Lajis, Khozirah Shaari, Daud Ahmad Israf, Johnson Stanslas, Umi Kalsom Yusuf, Salahuddin Mohd Raof

PMID16038556

ABSTRACT

A new labdane diterpene glucoside, curcumanggoside (1), together with nine known compounds, including labda-8(17),12-diene-15,16-dial (2), calcaratarin A (3), zerumin B (4), scopoletin, demethoxycurcumin, bisdemethoxycurcumin, 1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one, curcumin, and p-hydroxycinnamic acid, have been isolated from the rhizomes of Curcuma mangga. Their structures were determined using a combination of 1D (1H NMR, 13C NMR, DEPT) and 2D (COSY, HSQC, HMBC) NMR techniques. All diarylheptanoids and scopoletin showed significant antioxidant activity. Zerumin B, demethoxycurcumin, bisdemethoxycurcumin, and curcumin also exhibited cytotoxic activity against a panel of five human tumor cell lines.

MATERIALS

Product Number

Brand

Product Description

W218405

Sigma-Aldrich

Butylated hydroxytoluene, ≥99%, FCC, FG

90594

Supelco

Bisdemethoxycurcumin, analytical standard

34750

Sigma-Aldrich

2,6-Di-tert-butyl-4-methylphenol, purum, ≥99.0% (GC)

03762

Sigma-Aldrich

2,6-Di-tert-butyl-4-methylphenol, tested according to Ph. Eur.

47168

Supelco

3,5-Di-tert-butyl-4-hydroxytoluene, analytical standard

B1378

Sigma-Aldrich

2,6-Di-tert-butyl-4-methylphenol, ≥99.0% (GC), powder

S2500

Sigma-Aldrich

Scopoletin, ≥99%

T3634

Sigma-Aldrich

(+)-α-Tocopherol, from vegetable oil, Type V, ~1000 IU/g

T1539

Sigma-Aldrich

(+)-α-Tocopherol, Type VI, from vegetable oil, liquid (≥0.88M based on potency, density and molecular wt.), BioReagent, suitable for insect cell culture, ≥1000 IU/g