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T165

Sigma-Aldrich

S(+)-Terguride

solid

Synonym(s):

S(+)-N,N-Diethyl-N′([8α]-6-methylergolin-8-yl)urea, S(+)-Terguride (5R, 8S, 10R)

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About This Item

Empirical Formula (Hill Notation):
C20H28N4O
CAS Number:
37686-84-3
Molecular Weight:
340.46
EC Number:
253-624-2
MDL number:
MFCD00242729
UNSPSC Code:
12352200
PubChem Substance ID:
24278800

form

solid

optical activity

[α]20/D +28°, c = 0.2 in pyridine(lit.)

color

white

solubility

DMSO: soluble
H2O: insoluble
ethanol: soluble

SMILES string

[H][C@@]12Cc3c[nH]c4cccc(c34)[C@@]1([H])C[C@@H](CN2C)NC(=O)N(CC)CC

Gene Information

human ... DRD2(1813)
rat ... Drd2(24318)

Biochem/physiol Actions

Ergot derivative; dehydrogenated analog of lisuride; D2 dopamine receptor partial agonist.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301 + H311 + H331

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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T Akai et al.
Annals of neurology, 33(5), 507-511 (1993-05-01)
Behavioral effects of terguride, a partial dopamine D2 agonist, on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned parkinsonian cynomolgus monkeys were compared with those of the dopamine agonist apomorphine and the dopamine antagonist haloperidol. Terguride alone ameliorated the parkinsonism without inducing any sign of excitability

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