T103

Trifluperidol hydrochloride

• Synonym(s): 4′-Fluoro-4-[4-hydroxy-4-(α,α,α-trifluoro-m tolyl)piperidino]butyrophenone hydrochloride, R 2498, Triperidol
• Empirical Formula (Hill Notation): C₂₂H₂₃F₄NO₂ · HCl
• CAS Number: 2062-77-3
• Molecular Weight: 445.88
• NACRES: NA.77
• PubChem Substance ID: 24277941
• UNSPSC Code: 12352200
• EC Number: 218-170-1
• MDL number: MFCD00055195
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: desiccated

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• storage condition: desiccated
• color: white to off-white
• solubility: DMSO: ≥20 mg/mL, H₂O: soluble, ethanol: moderately soluble
• SMILES string: Cl.OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c3cccc(c3)C(F)(F)F
• InChI: 1S/C22H23F4NO2.ClH/c23-19-8-6-16(7-9-19)20(28)5-2-12-27-13-10-21(29,11-14-27)17-3-1-4-18(15-17)22(24,25)26;/h1,3-4,6-9,15,29H,2,5,10-14H2;1H
• InChI key: VYGQXRZAHIZHQV-UHFFFAOYSA-N
• Gene Information: human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816)

Description

Application

The interaction of Trifluperidol hydrochloride with NMDA receptors was studied in rat brain buffy coat membranes.[1]

Biochem/physiol Actions

Trifluperidol is a dopamine receptor antagonist with antipsychotic effects used in the treatment of schizophrenia.[2] This neuroleptic penetrates the brain and also affects the glial cells leading to increased release of proinflammatory cytokines.[3] It also alters the metabolism of carbohydrates and amino acids in the brain cortex.[4]

Safety Information

• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• pcodes: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges