Skip to Content
Merck

D054

R(+)-SCH-23390 hydrochloride

≥98% (HPLC), dopamine receptor antagonist, solid

Synonym(s):

R(+)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride

Sign In to View Organizational & Contract Pricing.

Select a Size

5 MG

PLN 474.00

10 MG

PLN 733.00

25 MG

PLN 1,970.00

100 MG

PLN 6,890.00

PLN 474.00


Please contact Customer Service for Availability

Request a Bulk Order

About This Item

Empirical Formula (Hill Notation):
C17H18ClNO · HCl
CAS Number:
Molecular Weight:
324.24
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
Storage condition:
desiccated, protect from light

Skip To

Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

R(+)-SCH-23390 hydrochloride, ≥98% (HPLC), solid

Quality Level

assay

≥98% (HPLC)

form

solid

optical activity

[α]/D +32.1°, c = 1 in DMF(lit.)

storage condition

desiccated, protect from light

color

white

solubility

H2O: >5 mg/mL

SMILES string

Cl[H].CN1CCc2cc(Cl)c(O)cc2[C@H](C1)c3ccccc3

InChI

1S/C17H18ClNO.ClH/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12;/h2-6,9-10,15,20H,7-8,11H2,1H3;1H/t15-;/m1./s1

InChI key

OYCAEWMSOPMASE-XFULWGLBSA-N

Gene Information

human ... DRD1(1812)

Related Categories

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
D047S143C130
assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

-

form

solid

form

crystalline

form

solid

form

solid

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

solubility

H2O: >5 mg/mL

solubility

H2O: >5 mg/mL, aqueous base: soluble (unstable)

solubility

H2O: 1.7 mg/mL, DMSO: >10 mg/mL, ethanol: 6.3 mg/mL

solubility

H2O: 3.7 mg/mL, aqueous base: unstable, ethanol: soluble

storage condition

desiccated, protect from light

storage condition

desiccated, protect from light

storage condition

desiccated

storage condition

-

color

white

color

white

color

white to light tan

color

tan

Application

R(+)-SCH-23390 hydrochloride has been used:
  • for intraperitoneal injection into experimental rats to study the role of D1 receptor in sensitization
  • as a D1 receptor-selective antagonist for intracranial drug infusions
  • as an antagonist of D1 receptor to study its effect on learning ability in fish

Biochem/physiol Actions

R(+)-SCH-23390 hydrochloride is a selective D1 dopamine receptor antagonist. It has greater binding capacity towards 5-hydroxytryptamine 2 (5-HT2) and 5-HT1C serotonin receptor subtypes in in vitro. R(+)-SCH-23390 has a half-life of about 25 minutes after administration. It is known to possess anti-stereotypic effect and cataleptogenic effect. It also has inhibitory effect on motor activity.

Features and Benefits

This compound is featured on the Dopamine Receptors and Potassium Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

Sold with the permission of Schering-Plough.

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Stimulation of dopamine D1 receptor improves learning capacity in cooperating cleaner fish
Messias Joao PM, et al.
Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character. Royal Society (Great Britain), 283(1823), 20152272-20152272 (2016)
L C Iorio et al.
The Journal of pharmacology and experimental therapeutics, 226(2), 462-468 (1983-08-01)
SCH 23390 [R-(+)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine-7-ol) possesses pharmacologic effects similar to standard antipsychotics, including selective supression of conditioned avoidance responding in rats and squirrel monkeys, blockade of apomorphine-induced stereotypy in rats and blockade of methamphetamine-induced lethality in aggregated mice. At effective doses in
Rewarding properties of methylphenidate: sensitization by prior exposure to the drug and effects of dopamine D1-and D2-receptor antagonists
Meririnne E, et al.
Journal of Pharmacology and Experimental Therapeutics, 298(2), 539-550 (2001)
Positive reinforcement mediated by midbrain dopamine neurons requires D1 and D2 receptor activation in the nucleus accumbens
Steinberg E E, et al.
PLoS ONE, 9(4), e94771-e94771 (2014)
SCH 23390: the first selective dopamine D1-like receptor antagonist
Bourne James A
Cns Drug Reviews, 7(4), 399-414 (2001)

Global Trade Item Number

SKUGTIN
D054-5MG04061833557822
D054-25MG04061833557815
D054-100MG04061832090108
D054-10MG04061833557808

Questions

1–7 of 7 Questions  
  1. How does the storage temperature relate to shipping conditions?

    1 answer
    1. The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.

      Helpful?

  2. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

  3. What is the melting point of Product D054, R(+)-SCH-23390 hydrochloride?

    1 answer
    1. The melting point is 247-248°C.

      Helpful?

  4. Is Product D054, R(+)-SCH-23390 hydrochloride, light sensitive?

    1 answer
    1. Yes, D054 is light sensitive. The powder form of the product, as well as solutions of the product, need to be protected from light.

      Helpful?

  5. Is Product D054, R(+)-SCH-23390 hydrochloride, only selective for the D1 dopamine receptor antagonist?

    1 answer
    1. The D054 is a selective D1 dopamine receptor antagonist, but is also selective to the D5.

      Helpful?

  6. What is the solution stability of Product D054, R(+)-SCH-23390 hydrochloride?

    1 answer
    1. Solutions may be stored for approximately 24 hours at 2-8 °C, protected from exposure to light.

      Helpful?

  7. How do I dissolve Product D054, R(+)-SCH-23390 hydrochloride?

    1 answer
    1. The D054 is tested for solublity in water at > 5 mg/mL. The product is also reported to be soluble in DMSO at 3mg/mL, and in ethanol at 2 mg/mL.

      Helpful?

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service