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Merck

HTR2A

5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled

Synonyms:
5-HT2A, HTR2
Species:
UniProtKB ID:
Gene ID:
  • Human(3356) Summary: This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
  • Mouse(15558) 5-hydroxytryptamine (serotonin) receptor 2A
  • Rat(29595) 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
  • dog(403882) 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
  • naked mole-rat(101708395) 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
  • Horse(100009685) 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
  • chicken(428070) 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
  • domestic guinea pig(100135545) 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
  • domestic cat(101081108) 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
  • cow(407230) 5-hydroxytryptamine (serotonin) receptor 2A

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Small Molecule - Agonist

Product Number
Description
Species
α-Methylserotonin maleate salt, ≥98% (HPLC),
Species
human
Aripiprazole solution, 1.0 mg/mL (50:50 Methanol/Water with 1% 1N HCl), ampule of 1 mL, certified reference material, Cerilliant®,
Species
human
Nortriptyline hydrochloride, ≥98% (HPLC), powder,
Species
human
Mianserin hydrochloride, ,
Species
human
Trazodone hydrochloride, ≥99% (HPLC), powder,
Species
human

Small Molecule - Allosteric Modulator

Product Number
Description
Species
DCEBIO, ≥98% (HPLC), solid,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
2,2-Diphenylethylamine, 96%,
Species
rat
Haloperidol solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Species
human
Haloperidol, European Pharmacopoeia (EP) Reference Standard,
Species
human
Haloperidol, United States Pharmacopeia (USP) Reference Standard,
Species
human
Haloperidol for system suitability, European Pharmacopoeia (EP) Reference Standard,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-HTR2A antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
western blot
Anti-5-HT-2A antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
ELISA
immunofluorescence

immunohistochemistry
Anti-Serotonin 2A (5-HT2A) Receptor (22-41) Rabbit pAb, liquid, Calbiochem®,
Species Reactivity
mouse, rat, sheep
Application
Anti-Serotonin receptor 2A/HTR2A Antibody, clone 9B11.1, clone 9B11.1, from mouse,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
Anti-HTR2A, affinity isolated antibody,
Species Reactivity
human, rat
Application
immunohistochemistry
western blot

Small Molecule - Blocker

Product Number
Description
Species
Mianserin hydrochloride, ,
Species
human
Trazodone hydrochloride, ≥99% (HPLC), powder,
Species
human
Pimozide, ,
Species
human, mouse, rat
Trimipramine maleate salt, ≥98% (TLC), powder,
Species
human
Zimelidine dihydrochloride, solid,
Species
human

Small Molecule - Inhibitor

Product Number
Description
Species
Trazodone hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®,
Species
human
Phenethylamine, ≥99%,
Species
rat, mouse, human
Phenethylamine, purified by redistillation, ≥99.5%,
Species
rat, mouse, human
Trazodone hydrochloride impurity standard, British Pharmacopoeia (BP) Reference Standard,
Species
human
Trazodone hydrochloride, United States Pharmacopeia (USP) Reference Standard,
Species
human

Small Molecule - Metabolite

Product Number
Description
Species
5-Hydroxyindole-3-acetic acid, ≥98% (HPLC), crystalline,
Species
human

Small Molecule - Mixed Agonist/Antagonist

Product Number
Description
Species
Mifepristone, ≥98%,
Species
human, mouse, rat
Haloperidol, powder,
Species
human, rat
Clozapine, ,
Species
human, rat

Small Molecule - Precursor

Product Number
Description
Species
5-Hydroxy-L-tryptophan, powder,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Htr2a,
Species
mouse