HSD11B2
hydroxysteroid (11-beta) dehydrogenase 2
Synonyms:
AME, AME1, HSD11K, HSD2, SDR9C3
Species:
Human HSD11B2 (3291), Mouse Hsd11b2 (15484), Rat Hsd11b2 (25117), Domestic Rabbit HSD11B2 (100009531), Zebrafish hsd11b2 (334098), cow HSD11B2 (282434), naked mole-rat Hsd11b2 (101712460), Horse HSD11B2 (100034124), chicken HSD11B2 (100857283), domestic guinea pig Hsd11b2 (100733422) ...More
UniProtKB ID:
Gene ID:
- Human(3291) Summary: There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension. [provided by RefSeq, Feb 2010]
- Mouse(15484) hydroxysteroid 11-beta dehydrogenase 2
- Rat(25117) hydroxysteroid 11-beta dehydrogenase 2
- Domestic Rabbit(100009531) hydroxysteroid (11-beta) dehydrogenase 2
- Zebrafish(334098) hydroxysteroid 11-beta dehydrogenase 2
- cow(282434) hydroxysteroid (11-beta) dehydrogenase 2
- naked mole-rat(101712460) hydroxysteroid (11-beta) dehydrogenase 2
- Horse(100034124) hydroxysteroid (11-beta) dehydrogenase 2
- chicken(100857283) hydroxysteroid (11-beta) dehydrogenase 2
- domestic guinea pig(100733422) hydroxysteroid (11-beta) dehydrogenase 2
- dog(489758) hydroxysteroid (11-beta) dehydrogenase 2
- domestic cat(100529249) hydroxysteroid (11-beta) dehydrogenase 2
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-HSD11B2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
immunohistochemistry
Anti-HSD11B2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-HSD11B2 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, guinea pig, human, mouse, rabbit, rat, sheep
Application
western blot
Anti-HSD11B2 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Small Molecule - Inhibitor
Product Number
Description
Species
esiRNA
Product Number
Description
Species