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Design and synthesis of novel CCR3 antagonists.

Bioorganic & medicinal chemistry letters (2003-09-25)
Leyi Gong, J Heather Hogg, James Collier, Robert S Wilhelm, Carol Soderberg
ABSTRACT

As part of our investigation into the development of potent CCR3 antagonists, a series of piperidine analogues was designed and prepared. Exploration of the piperidine core examined both the basicity and the location of a nitrogen, as well as conformational variants. The bicyclo-piperidine 24c was found to be the most potent inhibitor of CCR3 with an IC(50) of 0.0082 microM in the binding assay and 0.0024 microM in the chemotaxis assay.

MATERIALS
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Brand
Product Description

Sigma-Aldrich
2-Methoxy-4-nitrobenzoic acid, 98%
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25 mg
1 Estimated to ship on 03 February 2025
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CA$454.00
100 mg
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CA$1,540.00

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