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Leptophos

PESTANAL®, analytical standard

Synonym(s):

O-(4-Bromo-2,5-dichlorophenyl) O-methyl phenylphosphonothioate

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About This Item

Empirical Formula (Hill Notation):
C13H10BrCl2O2PS
CAS Number:
21609-90-5
Molecular Weight:
412.07
Beilstein:
2152663
EC Number:
244-472-8
MDL number:
MFCD00128037
UNSPSC Code:
41116107
PubChem Substance ID:
329754497
NACRES:
NA.24

grade

analytical standard

product line

PESTANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
NMR: suitable
gas chromatography (GC): suitable

mp

71-73 °C

suitability

passes test for identity (NMR)

application(s)

agriculture
environmental

format

neat

storage temp.

2-8°C

SMILES string

COP(=S)(Oc1cc(Cl)c(Br)cc1Cl)c2ccccc2

InChI

1S/C13H10BrCl2O2PS/c1-17-19(20,9-5-3-2-4-6-9)18-13-8-11(15)10(14)7-12(13)16/h2-8H,1H3

InChI key

CVRALZAYCYJELZ-UHFFFAOYSA-N

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General description

Leptophos, an organophosphorus insecticide found to be persistent in the environment, shows neurotoxic effects in humans. Its mode of action for pest control involves the inhibition of acetylcholinesterase enzyme activity.

Application

Leptophos may be used as an analytical reference standard for the quantification of the analyte in vegetables using solid phase micro-extraction coupled with gas chromatography-flame photometric detector (SPME-GC-FPD).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

PESTANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

Hazard Statements

H300,H311,H370,H410

Hazard Classifications

Acute Tox. 2 Oral - Acute Tox. 3 Dermal - Aquatic Acute 1 - Aquatic Chronic 1 - STOT SE 1

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCM1323
BCCJ4233
BCCC5203
BCBZ7738
BCBW5130

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Photodegradation of leptophos.
Riskallah RM, et al.
Bulletin of Environmental Contamination and Toxicology, 23(1), 636-641 (1979)
Determination of organophosphorus pesticide residues in vegetables using solid phase micro-extraction coupled with gas chromatography-flame photometric detector.
Sapahin AH, et al.
Arabian Journal of Chemistry, 23(1), 636-641 (2014)
F Y Piao et al.
The Journal of toxicological sciences, 20(5), 609-617 (1995-11-01)
Delayed neurotoxicity induced by leptophos, an organophosphorus insecticide, was intensified in hens when phenylmethylsulfonyl fluoride (PMSF) at dose of 30, 60, and 120 mg/kg body weight was administered at different time intervals (24 hr, 3 days, and 5 days) for
M Farage-Elawar et al.
Journal of toxicology and environmental health, 23(2), 217-228 (1988-01-01)
The effects of multiple doses of desbromoleptophos, fenitrothion, and pure fenthion on brain acetylcholinesterase (AChE), brain neurotoxic esterase (NTE), and walking were investigated in immature chicks, below the age of sensitivity to organophosphorus ester-induced delayed neurotoxicity (OPIDN). Ten milligrams per
J Anthony
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes, 28(3), 275-290 (1993-06-01)
Changes in acetylcholinesterase (AChE) levels in the brain and various segments of the spinal cord of birds fed subchronic repeated oral doses of 0-(4-bromo-2,5 dichlorophenyl) 0-methyl phenylphosphonothioate, (leptophos, 15 mg/kg/day) is reported. The effect of leptophos on the histological structure
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