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  • Connecting Neuronal Cell Protective Pathways and Drug Combinations in a Huntington's Disease Model through the Application of Quantitative Systems Pharmacology.

Connecting Neuronal Cell Protective Pathways and Drug Combinations in a Huntington's Disease Model through the Application of Quantitative Systems Pharmacology.

Scientific reports (2017-12-21)
Fen Pei, Hongchun Li, Mark J Henderson, Steven A Titus, Ajit Jadhav, Anton Simeonov, Murat Can Cobanoglu, Seyed H Mousavi, Tongying Shun, Lee McDermott, Prema Iyer, Michael Fioravanti, Diane Carlisle, Robert M Friedlander, Ivet Bahar, D Lansing Taylor, Timothy R Lezon, Andrew M Stern, Mark E Schurdak
PMID29259176
ABSTRACT

Quantitative Systems Pharmacology (QSP) is a drug discovery approach that integrates computational and experimental methods in an iterative way to gain a comprehensive, unbiased understanding of disease processes to inform effective therapeutic strategies. We report the implementation of QSP to Huntington's Disease, with the application of a chemogenomics platform to identify strategies to protect neuronal cells from mutant huntingtin induced death. Using the STHdh