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  • Berberine suppresses LPS-induced inflammation through modulating Sirt1/NF-κB signaling pathway in RAW264.7 cells.

Berberine suppresses LPS-induced inflammation through modulating Sirt1/NF-κB signaling pathway in RAW264.7 cells.

International immunopharmacology (2017-09-11)
Hao Zhang, Yun Shan, Yun Wu, Chuanchong Xu, Xizhong Yu, Juan Zhao, Jing Yan, Wenbin Shang
PMID28888780
ABSTRACT

Chronic inflammation is a major contributing factor in the pathogenesis of many diseases. Natural product berberine (BBR) exhibits potent anti-inflammatory effect in vitro and in vivo, while the underlying mechanisms remain elusive. Sirt1, a NAD