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  • Immunomodulators targeting MARCO expression improve resistance to postinfluenza bacterial pneumonia.

Immunomodulators targeting MARCO expression improve resistance to postinfluenza bacterial pneumonia.

American journal of physiology. Lung cellular and molecular physiology (2017-04-15)
Muzo Wu, John G Gibbons, Glen M DeLoid, Alice S Bedugnis, Rajesh K Thimmulappa, Shyam Biswal, Lester Kobzik
PMID28408365
ABSTRACT

Downregulation of the alveolar macrophage (AM) receptor with collagenous structure (MARCO) leads to susceptibility to postinfluenza bacterial pneumonia, a major cause of morbidity and mortality. We sought to determine whether immunomodulation of MARCO could improve host defense and resistance to secondary bacterial pneumonia. RNAseq analysis identified a striking increase in MARCO expression between