- Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing.
Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing.
Nature communications (2017-07-13)
Manuel Blandino-Rosano, Rebecca Barbaresso, Margarita Jimenez-Palomares, Nadejda Bozadjieva, Joao Pedro Werneck-de-Castro, Masayuki Hatanaka, Raghavendra G Mirmira, Nahum Sonenberg, Ming Liu, Markus A Rüegg, Michael N Hall, Ernesto Bernal-Mizrachi
PMID28699639
ABSTRACT
Deregulation of mTOR complex 1 (mTORC1) signalling increases the risk for metabolic diseases, including type 2 diabetes. Here we show that β-cell-specific loss of mTORC1 causes diabetes and β-cell failure due to defects in proliferation, autophagy, apoptosis and insulin secretion by using mice with conditional (βraKO) and inducible (MIP-βraKO
MATERIALS