A comparison of PC oxidation products as detected by MALDI-TOF and ESI-IT mass spectrometry.

Oxidized (phospho)lipids are of paramount interest for different reasons: besides their in vivo relevance as markers of inflammatory diseases, they are often needed in the laboratory to study the response of selected cells to oxidized lipids. Mass spectrometry (MS) is nowadays one of the most powerful methods to identify lipid oxidation products. Although MALDI and ESI MS are both widely used, it is so far not clear whether all potential phospholipid oxidation products can be detected by both methods This aspect will be studied here using NaMnO