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  • In vitro protein tyrosine phosphatase 1B inhibitory phenols from the seeds of Psoralea corylifolia.

In vitro protein tyrosine phosphatase 1B inhibitory phenols from the seeds of Psoralea corylifolia.

Planta medica (2005-01-29)
Youn-Chul Kim, Hyuncheol Oh, Beom Seok Kim, Tai-Hyun Kang, Eun-Kyoung Ko, Yu Mi Han, Bo Yeon Kim, Jong Seog Ahn
PMID15678382
ABSTRACT

Protein tyrosine phosphatase 1B plays a major role in the negative regulation of insulin signaling, and this establishes protein tyrosine phosphatase 1B as an attractive therapeutic target for diabetes. Bioassay-guided fractionation of the EtOAc-soluble extract of the seeds of Psoralea corylifolia afforded two protein tyrosine phosphatase 1B inhibitory compounds, psoralidin (1) and bakuchiol (2), along with inactive corylin. Compounds 1 and 2 inhibited PTP1B activity in a dose-dependent manner, displaying IC50 values of 9.4 +/- 0.5 microM and 20.8 +/- 1.9 microM, respectively.