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  • Biphasic Synthesis of Large-Pore and Well-Dispersed Benzene Bridged Mesoporous Organosilica Nanoparticles for Intracellular Protein Delivery.

Biphasic Synthesis of Large-Pore and Well-Dispersed Benzene Bridged Mesoporous Organosilica Nanoparticles for Intracellular Protein Delivery.

Small (Weinheim an der Bergstrasse, Germany) (2015-02-06)
Yannan Yang, Yuting Niu, Jun Zhang, Anand Kumar Meka, Hongwei Zhang, Chun Xu, Chun Xiang Cynthia Lin, Meihua Yu, Chengzhong Yu
ABSTRACT

Large pore (4.6-7.6 nm) and well-dispersed benzene bridged mesoporous organosilica nanoparticles with uniform particle size of ≈50 nm are prepared via a biphasic approach. They can be directly used as nanocarriers without surface modification for the intracellular delivery of therapeutic proteins.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Isopropyl alcohol, ≥99.7%, FCC, FG
Sigma-Aldrich
2-Propanol, BioUltra, for molecular biology, ≥99.5% (GC)
Sigma-Aldrich
2-Propanol, anhydrous, 99.5%
Sigma-Aldrich
Triethanolamine, ≥99.0% (GC)
Sigma-Aldrich
Toluene, anhydrous, 99.8%
Sigma-Aldrich
DAPI, for nucleic acid staining
Sigma-Aldrich
2-Propanol, for molecular biology, BioReagent, ≥99.5%
Sigma-Aldrich
2-Propanol, electronic grade, 99.999% trace metals basis