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  • Syntheses and optimization of new GS39783 analogues as positive allosteric modulators of GABA B receptors.

Syntheses and optimization of new GS39783 analogues as positive allosteric modulators of GABA B receptors.

Bioorganic & medicinal chemistry letters (2007-09-22)
Sébastien Guery, Philipp Floersheim, Klemens Kaupmann, Wolfgang Froestl
PMID17884493
ABSTRACT

The optimization of GS39783 into potent, selective, and safe positive allosteric modulators of GABA(B) receptors is presented.