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Possible mechanism of antidepressant effect of L-sulpiride.

Clinical neuropharmacology (1990-01-01)
G Serra, A Forgione, P S D'Aquila, M Collu, W Fratta, G L Gessa
PMID2199037
ABSTRACT

L-Sulpiride is a dopamine (DA)-receptor blocker that acts as an antidepressant at low doses. We have reviewed evidence suggesting that the antidepressant effect of L-sulpiride may depend on the activation of DA transmission secondary to the blockade of DA autoreceptors.