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  • 1,2,5-Thiadiazole derivatives are potent and selective ligands at human 5-HT1A receptors.

1,2,5-Thiadiazole derivatives are potent and selective ligands at human 5-HT1A receptors.

Bioorganic & medicinal chemistry letters (2001-05-01)
A L Sabb, R L Vogel, M G Kelly, Y Palmer, D L Smith, T H Andree, L E Schechter
PMID11327592
ABSTRACT

Amino acid derivatives of 1,2,5-thiadiazol-3-yl-piperazine related to (+)-WAY-100135 and WAY-100635 are potent 5-HT1A receptor agonists and antagonists, which have selective affinity for 5-HT1A receptors versus alpha1 and dopamine (D2, D3, and D4) receptors.