First synthesis of dimethyl-1H-isochromeno[3,4-b]carbazoles.

First synthesis of dimethyl-1H-isochromeno[3,4-b]carbazoles.

Natural product communications (2009-09-08)

Nguyen Manh Cuong, Heike Wilhelm, Andrea Porzel, Ludger Wessjohann

PMID19731593

ABSTRACT

The first synthesis of isochromene fused carbazols, (4aS, 13bR)-2,5,5-trimethyl-3,4,4a,5,8,13b-hexahydroisochromeno[3,4-b]carbazole (2) and its epi-isomer 3 by condensation of citral and 2-hydroxycarbazole using Ti(OEt)4 and MeAlC12 as catalysts is described.