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[Study of plasma and hepatic hydrolysis of nitroxinil derivatives].

Annales pharmaceutiques francaises (1996-01-01)
G Baziard-Mouysset, M Alvinerie, P Galtier, M Ane-Margail, R Floch, M Payard
ABSTRACT

Seven esters derivatives of Nitroxinil were prepared and their structures were assigned by IR and 1H-NMR spectroscopy. The rate of plasma and hepatic hydrolysis were evaluated in vitro in sheep and rabbit. In view of this profile of activity, pivaloyl derivative merits evaluation, in vivo.