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  • Structure--activity relationships of azasugar-based MMP/ADAM inhibitors.

Structure--activity relationships of azasugar-based MMP/ADAM inhibitors.

Bioorganic & medicinal chemistry letters (2003-07-23)
Hideki Moriyama, Takahiro Tsukida, Yoshimasa Inoue, Hirosato Kondo, Kohichiro Yoshino, Shin-ichiro Nishimura
PMID12873504
ABSTRACT

In order to investigate structure-activity relationships of azasugar series toward metalloproteinases, we synthesized and evaluated several azasugar-based compounds. As a result, it was found that 4-phenoxybenzene derivative 3 having 2R,3R,4R,5S-configurations exhibited most potent inhibitory activities against matrix metalloproteinase-1, -3 and -9 and TACE.